Author + information
- Received February 24, 2020
- Revision received May 5, 2020
- Accepted May 6, 2020
- Published online September 28, 2020.
- aCenter for Mitochondrial and Epigenomic Medicine, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
- bDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
- ↵∗Address for correspondence:
Dr. Liming Pei, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, CTRB 6018, 3501 Civic Center Boulevard, Philadelphia, Pennsylvania 19104.
• The heart uses an endocrine mechanism to communicate with the rest of the body.
• Heart-derived hormones, such as GDF-15, myostatin, and ANP/BNP, share common features, including synthesis, regulation, and function, and they coordinate the functions of the heart and target organs.
• Additional heart-secreted factors play important autocrine and/or paracrine roles in local cardiac remodeling.
• Future studies in the field of cardiac endocrinology will further advance the understanding of the intricate communications between the heart and the rest of the body.
The heart plays a central role in the circulatory system and provides essential oxygen, nutrients, and growth factors to the whole organism. The heart can synthesize and secrete endocrine signals to communicate with distant target organs. Studies of long-known and recently discovered heart-derived hormones highlight a shared theme and reveal a unified mechanism of heart-derived hormones in coordinating cardiac function and target organ biology. This paper reviews the biochemistry, signaling, function, regulation, and clinical significance of representative heart-derived hormones, with a focus on the cardiovascular system. This review also discusses important and exciting questions that will advance the field of cardiac endocrinology.
Drs. Zhao and Pei are supported by the Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Medical Research Program (Awards W81XWH-16-1-0400, W81XWH2010042, W81XWH2010089), National Institutes of Health DK111495, pilot awards from the Diabetes Research Center at the University of Pennsylvania (NIH DK19525), and the WW Smith Charitable Trust (#H1407). Both authors have reported that they have no relationships relevant to the contents of this paper to disclose.
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Basic to Translational Science author instructions page.
- Received February 24, 2020.
- Revision received May 5, 2020.
- Accepted May 6, 2020.
- 2020 The Authors