Author + information
- Received April 7, 2020
- Accepted April 7, 2020
- Published online May 25, 2020.
- Deepak Atri, MD∗,
- Hasan K. Siddiqi, MD, MSCR∗,
- Joshua P. Lang, MD,
- Victor Nauffal, MD,
- David A. Morrow, MD, MPH and
- Erin A. Bohula, MD, DPhil∗ ()
- Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
- ↵∗Address for correspondence:
Dr. Erin A. Bohula, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, 350 Longwood Avenue, First Office Floor, Boston, Massachusetts 02115.
• SARS-CoV-2, the infection responsible for COVID-19, has spread globally, leading to a devastating loss of life. In a few short months, the clinical and scientific communities have rallied to rapidly evolve our understanding of the mechanism(s) of disease and potential therapeutics.
• This review discusses the current understanding of the basic virology of SARS-CoV-2 and the epidemiology, clinical manifestations (including cardiovascular), and mortality of COVID-19. A detailed review of the viral life cycle and putative mechanism(s) of injury frames the discussion of possible preventative and therapeutic strategies.
• The ongoing, unprecedented collective effort will, without a doubt, advance our ability to prevent the spread and optimally care for patients suffering from COVID-19.
Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As it spreads across the world, it has overwhelmed health care systems, strangled the global economy, and led to a devastating loss of life. Widespread efforts from regulators, clinicians, and scientists are driving a rapid expansion of knowledge of the SARS-CoV-2 virus and COVID-19. The authors review the most current data, with a focus on the basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. The authors discuss the basic virology, epidemiology, clinical manifestation, multiorgan consequences, and outcomes. With a focus on cardiovascular complications, they propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
↵∗ Drs. Atri and Siddiqi contributed equally to this work and are joint first authors.
The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Basic to Translational Science author instructions page.
- Received April 7, 2020.
- Accepted April 7, 2020.
- Central Illustration
- Basic Virology of SARS-CoV-2
- Epidemiology and Clinical Manifestations of SARS-CoV-2
- Putative Mechanisms of Cardiovascular Manifestations in SARS-CoV-2
- Potential Targeted or Disease-Modifying Treatments in SARS-CoV-2
- Crisis Standards of Care and Ethical Resource Allocation