Author + information
- Salvatore Carbone, MSa,b,∗ (, )
- Justin M. Canada, MS, RCEPa,c,
- Leo F. Buckley, PharmDd,
- Cory R. Trankle, MDa,
- Hayley E. Billingsley, RDa,
- Dave L. Dixon, PharmDd,
- Adolfo G. Mauro, MSa,
- Sofanit Dessie, MDa,
- Dinesh Kadariya, MDa,
- Eleonora Mezzaroma, PhDd,
- Raffaella Buzzetti, MDb,
- Ross Arena, PhDe,
- Benjamin W. Van Tassell, PharmDd,
- Stefano Toldo, PhDa and
- Antonio Abbate, MD, PhDa
- aVCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
- bDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy
- cKinesiology and Health Sciences, Virginia Commonwealth University, Richmond, Virginia
- dDepartment of Pharmacotherapy and Outcome Sciences, Virginia Commonwealth University, Richmond, Virginia
- eDepartment of Physical Therapy, College of Applied Health Sciences, University of Illinois, Chicago, Illinois
- ↵∗Address for correspondence:
Dr. Salvatore Carbone, VCU Pauley Heart Center, Virginia Commonwealth University, West Hospital, 5th Floor, Room 520, 1200 East Broad Street, PO Box 980204, Richmond, Virginia 23298.
• The effects of UFA on CRF in patients with HFpEF are unknown.
• In obese HFpEF patients, UFA consumption analyzed with a validated 24-h dietary recall was positively associated with improved body composition, cardiac diastolic function and greater CRF, measured as peak VO2 at maximal cardiopulmonary exercise testing. Conversely, sugars consumption was associated with worse CRF.
• In mice, an isocaloric high-fat diet, high in UFA and low in saturated fat prevented cardiac diastolic dysfunction measured with echocardiography and body weight gain in a model of cardiac dysfunction and obesity induced by Western diet, despite similar total caloric intake.
• A high-UFA diet is associated with preservation of CRF in patients with HFpEF and cardiac function in the mouse.
Heart failure with preserved ejection fraction (HFpEF) is associated with obesity and, indirectly, with unhealthy diet. The role of dietary components in HFpEF is, however, largely unknown. In this study, the authors showed that in obese HFpEF patients, consumption of unsaturated fatty acids (UFA), was associated with better cardiorespiratory fitness, and UFA consumption correlated with better diastolic function and with greater fat-free mass. Similarly, mice fed with a high-fat diet rich in UFA and low in sugars had preserved myocardial function and reduced weight gain. Randomized clinical trials increasing dietary UFA consumption and reducing sugar consumption are warranted to confirm and expand our findings.
This study was supported by the National Institutes of Health (grants R34HL118348 and UL1TR000058). Dr. Carbone is supported by a Mentored Clinical and Population Research Award from the American Heart Association (16MCPRP31100003). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
All authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Basic to Translational Science author instructions page.
- Received April 4, 2017.
- Revision received May 22, 2017.
- Accepted June 1, 2017.
- 2017 The Authors