Table 2

Plasma Furosemide Noncompartmental PK Parameters Following IV Administration

Cmax (ng/ml)Tmax (h)AUClast (h ∙ ng/ml)AUC (h ∙ ng/ml)AUCext (%)λz (1/h)t½ (h)V (l)CL (l/h)
n151515151515151515
Mean8,580N/A13,00013,2000.9120.2772.5524.46.71
SD2,540N/A40504,1700.6310.03650.3399.152.31
% CV29.5N/A31.131.669.213.213.337.534.5
Geometric mean8,270N/A12,40012,6000.7290.2742.5323.26.37
Geometric % CV28.4N/A33.333.782.213.313.331.233.7
Minimum5,0600.086,5406,6000.1990.2182.0015.83.83
Median8,2302.0812,80012,9000.6660.2752.5223.06.20
Maximum13,8002.0820,50020,9002.470.3473.1853.112.1

λz = apparent terminal phase elimination rate constant; AUC = area under the curve; AUC = plasma concentration to infinity; AUCext = percentage of AUC that is extrapolated beyond the last measurable concentration; AUClast = last measurable plasma concentration; CL = systemic clearance; Cmax = peak plasma concentration; CV = coefficient of variation; N/A = not available; t½ = terminal phase elimination half-life; Tmax = time to peak plasma concentration; V = systemic volume of distribution.