Table 3

Plasma Furosemide Noncompartmental PK Parameters Following Subcutaneous Administration

Cmax (ng/ml)Tmax (h)AUClast (h ∙ ng/ml)AUC (h ∙ ng/ml)AUCext (%)λz (1/h)t½ (h)F (%)V/F (L)CL/F (L/h)
n15151515151515151515
Mean2,040N/A13,00013,1001.050.2383.16100.028.56.71
SD449N/A4,0004,0101.290.07320.91110.55.282.21
% CV22.0N/A30.830.6123.030.828.810.518.532.9
Geometric mean1,990N/A12,40012,5000.7100.2283.0499.628.06.4
Geometric % CV23.0N/A33.332.899.030.430.410.519.832.8
Minimum1,3401.007,1107,5200.2180.1481.7881.017.73.84
Median2,0404.0012,90012,9000.6140.2173.2010028.86.2
Maximum2,7805.0820,70020,8005.420.3904.6912136.510.6

Abbreviations as in Table 2.