Inhibition of SGLT2 Reduces Sympathetic Innervation in the Kidney of Hypertensive BPH/2J Mice
Representative immunohistochemistry images of tyrosine hydroxylase expression in kidneys from (A) untreated BPH/2J mice or (B) BPH/2J mice treated with dapagliflozin. Tyrosine hydroxylase staining is indicated with arrows. Magnification 200×. (C) Quantitation of tyrosine hydroxylase expression in kidneys from BPH/2J mice, n = 4–6 mice/group. (D) Norepinephrine content in kidneys from BPH/2J mice with or without dapagliflozin treatment, n = 15–19 mice/group. (E) Renin concentration in serum from BPH/2J mice with or without dapagliflozin treatment, n = 14–18 mice/group. *p = 0.05; **p ≤ 0.01; all data presented as mean ± SEM. Abbreviation as in Figure 1.