Chemical Denervation With 6-OHDA Prevents the Increase in Blood Pressure and Lowers the Fasting Glucose and Renal SGLT2 Levels in Hypertensive BPH/2J Mice
Effects of 6-hydroxydopamine (6-OHDA) (100 mg/kg) on (A) systolic blood pressure (SBP), (B) diastolic blood pressure (DBP), and (C) mean arterial pressure (MAP) were measured using a tail-cuff apparatus. (D) Fasting glucose was measured after a week of treatment. (E) Intensity of sodium glucose cotransporter 2 (SGLT2) in proximal tubules in kidneys was rated on a scale 0–3 per field of view (FOV): 0 = no staining, 1 = low staining, 2 = intermediate staining, 3 = highest staining. n = 7–9 mice/group. *p < 0.05; **p < 0.001; all data presented as mean ± SEM.