cMyBP-C Phosphorylated Mimetic (t3SD) Demonstrated Better Preservation of Diastolic and Systolic Functions With Aging
(A) Sample tissue Doppler traces showed that cMyBP-C(t3SD) myocardium relaxes at a much faster velocity (e′) during early diastole at 15 months of age. (B) All mice models showed similar heart rates. (C) cMyBP-C(t3SD) showed better preservation of ejection fraction (EF). (D) Only cMyBP-C(t3SD) showed preserved posterior wall thickness during diastole (PWd) with aging. (E) cMyBP-C(t3SD) exhibited faster peak myocardial relaxation velocity (e′) that was preserved with aging. (F) cMyBP-C(t3SD) showed preservation of E/e′ with aging. (G) Peak myocardial contraction velocity (Sa) was preserved in cMyBP-C(t3SD) hearts. cMyBP-C(tWT), 3 months: n = 11; 12 months: n = 9; 15 months: n = 11; and 18 months: n = 7. cMyBP-C(t3SA), 3 months: n = 11; 12 months: n = 8; 15 months: n = 15; and 18 months: n = 10. cMyBP-C(t3SD), 3 months: n = 10; 12 months: n = 13; 15 months: n = 10; and 18 months: n = 8. Data are presented as dot plots with mean ±SD. *p < 0.05 versus tWT. #p < 0.05 versus t3SD. ˆp < 0.05 for 3 months versus 18 months within the same strain according to an independent Student’s t-test. All comparisons between 3 strains were analyzed with an analysis of variance post hoc Tukey method. Multiple comparisons between all time points within the same strain were not performed.