De-phosphorylated Mimetic cMyBP-C(t3SA) Exhibits Signs of Heart Failure
(A) Nonfasting blood glucose levels were similar in all 3 mice models at 15 to 18 months of age. (B) All 3 mice models exhibited mean blood pressures within 95 to 120 mm Hg; however, cMyBP-C(t3SD) mice showed significantly higher blood pressure. (C) cMyBP-C(t3SA) showed an increased lung weight to body weight ratio (LW/BW), suggesting pulmonary edema. (D and E) cMyBP-C(t3SA) showed increased heart weight to body weight (HW/BW) and increased heart weight to tibia length (HW/TL) ratios, suggesting hypertrophy. Comparisons between 3 strains were analyzed with an analysis of variance post hoc Tukey method. Data are presented as dot plots with mean ±SD.