Impact of Canagliflozin in Nondiabetic ZL and Diabetic ZDF Rats
(A) Canagliflozin had a rapid and sustained impact upon circulating blood glucose in the diabetic ZDF rats compared with the untreated animals. By contrast, canagliflozin had no impact upon circulating blood glucose in the nondiabetic ZL rats (p = 0.002; n = 8 to 10 per group). (B) After 4 week’s treatment, canagliflozin had little impact upon blood urea nitrogen in either ZL or ZDF rats (p = NS; n = 6 to 8 per group). (C) As with BUN, there was little impact from 4-week oral canagliflozin administration in either ZL or ZDF rats upon albumin/creatinine ratios (p = NS; n = 4 to 8 per group). (D) Kaplan-Meier survival curve. Two animals, both in the control diabetic ZDF group, had to be euthanized for severe urinary sepsis. All other groups completed without events. Abbreviations as in Figure 1.