Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice
Martin Mackasey, Emmanuel E. Egom, Hailey J. Jansen, Rui Hua, Motahareh Moghtadaei, Yingjie Liu, Jaspreet Kaur, Megan D. McRae, Oleg Bogachev, Sara A. Rafferty, Gibanananda Ray, Adam W. Kirkby and Robert A. Rose
Assessment of Heart Rate and SAN Function in Wild-Type and NPR-C−/− Mice Treated With Ang II
(A) Representative ECG recordings obtained during intracardiac programmed stimulation in anesthetized wild-type and NPR-C−/− mice treated with saline or Ang II to measure SNRT. (B) Summary of heart rate in wild-type and NPR-C−/− mice treated with saline or Ang II. (C) Summary of cSNRT in wild-type and NPR-C−/− mice treated with saline or Ang II. *p < 0.001 versus saline; +p < 0.001 versus wild type by 2-way analysis of variance with Tukey post hoc test; n = 28 mice for wild-type/saline treatment, 29 mice for wild-type/Ang II treatment, 19 mice for NPR-C−/−/saline treatment, and 19 mice for NPR-C−/−/Ang II treatment. Ang II = angiotensin II; cSNRT = corrected SNRT; ECG = electrocardiography; NPR-C= natriuretic peptide receptor C; SAN = sinoatrial node; SNRT = sinoatrial node recovery time.