Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension
Lauren Brash, Gareth D. Barnes, Melanie J. Brewis, A. Colin Church, Simon J. Gibbs, Luke S.G.E. Howard, Geeshath Jayasekera, Martin K. Johnson, Neil McGlinchey, Joelle Onorato, Joanne Simpson, Colin Stirrat, Stephen Thomson, Geoffrey Watson, Martin R. Wilkins, Carrie Xu, David J. Welsh, David E. Newby and Andrew J. Peacock
Pulmonary vascular resistance during infusion of (Pyr1)apelin-13 or matched saline placebo in patients with pulmonary arterial hypertension while undergoing exercise protocol. A zero reflects resting measurements, raise reflects measurements taken with legs raised in ergometers pedals at rest, then further measurements at 20% and 40% of previous erect maximal cardiopulmonary exercise test performance. Data are reported as mean ± SEM. *p = 0.019, 2-way analysis of variance with post hoc Bonferroni tests. PVR = pulmonary vascular resistance.