JACC: Basic to Translational Science
Diabetes Exacerbates Myocardial Ischemia Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation
Dandan Wang, Xiaoyue Hu, Seung Hee Lee, Feng Chen, Kai Jiang, Zizhuo Tu, Zejian Liu, Jing Du, Li Wang, Chaoying Yin, Yu Liao, Hongcai Shang, Kathleen A. Martin, Raimund I. Herzog, Lawrence H. Young, Li Qian, John Hwa and Yaozu Xiang
Table 1
Table 1
Survival in WT and Diabetic Mice Subjected to MI or I/R
Mice Type | 1-Week Survival | 4-Week Survival | ||
---|---|---|---|---|
MI | MI + Insulin | I/R | I/R + Insulin | |
WT (C57BL/6J) | 58% | NA | 91% | 100% |
STZ (T1DM) | 14%∗ | 63%† | 31%‡ | 77%§ |
Db/db (T2DM) | NA | NA | 69% | 25%‖ |
Survival curves were analyzed using GraphPad Prism 6 (GraphPad Software, La Jolla, California) (a log-rank [Mantel-Cox] test).
I/R = ischemia reperfusion; MI = myocardial infarction; STZ = streptozotocin; WT = wild-type.
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