JACC: Basic to Translational Science
May 2018 DOI: 10.1016/j.jacbts.2018.01.005
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Novel Translational Methods

Diabetes Exacerbates Myocardial Ischemia Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation

Dandan Wang, Xiaoyue Hu, Seung Hee Lee, Feng Chen, Kai Jiang, Zizhuo Tu, Zejian Liu, Jing Du, Li Wang, Chaoying Yin, Yu Liao, Hongcai Shang, Kathleen A. Martin, Raimund I. Herzog, Lawrence H. Young, Li Qian, John Hwa and Yaozu Xiang

Table 1

Table 1

Survival in WT and Diabetic Mice Subjected to MI or I/R

Mice Type1-Week Survival4-Week Survival
MIMI + InsulinI/RI/R + Insulin
WT (C57BL/6J)58%NA91%100%
STZ (T1DM)14%∗63%†31%‡77%§
Db/db (T2DM)NANA69%25%‖

Survival curves were analyzed using GraphPad Prism 6 (GraphPad Software, La Jolla, California) (a log-rank [Mantel-Cox] test).

I/R = ischemia reperfusion; MI = myocardial infarction; STZ = streptozotocin; WT = wild-type.

  • ↵∗ MI, STZ vs. WT, 14% vs. 58%; p = 0.0099.

  • ↵† MI, STZ + insulin vs. STZ, 63% vs. 14%; p < 0.0065.

  • ↵‡ I/R, STZ vs. WT, 31% vs. 91%; p = 0.0023.

  • ↵§ I/R, STZ + insulin vs. STZ, 31% vs. 77%; p = 0.0223.

  • ↵‖ I/R, db/db + insulin vs. db/db, 25% vs. 69%; p = 0.0241.

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