Diabetes Exacerbates Myocardial Ischemia Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation
Dandan Wang, Xiaoyue Hu, Seung Hee Lee, Feng Chen, Kai Jiang, Zizhuo Tu, Zejian Liu, Jing Du, Li Wang, Chaoying Yin, Yu Liao, Hongcai Shang, Kathleen A. Martin, Raimund I. Herzog, Lawrence H. Young, Li Qian, John Hwa and Yaozu Xiang
Down-Regulation of miR-24 in Response to Insulin Infusion in Human Plasma
Human plasma insulin (A), glucose (B), and miR-24 level (C) response to insulin infusion, normalized to spiked-in cel-miR-238. (D) Correlation of plasma miR-24 levels with insulin levels in T1DM patients. (E) Comparison of human plasma miR-24 levels in type 1 diabetes mellitus (T1DM) (n = 13) and type 2 diabetes mellitus (T2DM) (n = 27), normalized to spiked-in cel-miR-238; analysis of covariance was conducted while adjusting for age and sex. (F) Comparison of human plasma miR-24 levels in healthy subjects (HC) (n = 10) and T2DM without insulin therapy (n = 13) or with insulin therapy (n = 13), normalized to spiked-in cel-miR-238; analysis of covariance was conducted while adjusting for age and sex.