Diabetes Exacerbates Myocardial Ischemia Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation
Dandan Wang, Xiaoyue Hu, Seung Hee Lee, Feng Chen, Kai Jiang, Zizhuo Tu, Zejian Liu, Jing Du, Li Wang, Chaoying Yin, Yu Liao, Hongcai Shang, Kathleen A. Martin, Raimund I. Herzog, Lawrence H. Young, Li Qian, John Hwa and Yaozu Xiang
Diabetes Exacerbates Myocardial Infarction and Ischemia Reperfusion Injury
(A) Comparison of fasting blood glucose levels in diabetic mouse models (n = 10 to 12). (B) Enzyme-linked immunosorbent assay analysis of fasting plasma insulin levels in diabetic mouse models (n = 8 to 10). (C to E) Comparison of infarct size between wild-type (WT) and db/db (leptin receptor knockout) mice subjected to ischemia for 20 min and reperfusion for 3 h. (F) Survival curve (log-rank [Mantel-Cox] test) of WT, streptozotocin (STZ)-induced type 1 diabetes (with or without insulin therapy), and db/db (with or without insulin therapy) subjected to 20 min ligation of left anterior descending coronary artery (LAD) followed by reperfusion (I/R) for 4 weeks.