Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models
Maria K. Schweitzer, Fabiola Wilting, Simon Sedej, Lisa Dreizehnter, Nathan J. Dupper, Qinghai Tian, Alessandra Moretti, Ilaria My, Ohyun Kwon, Silvia G. Priori, Karl-Ludwig Laugwitz, Ursula Storch, Peter Lipp, Andreas Breit, Michael Mederos y Schnitzler, Thomas Gudermann and Johann Schredelseker
Efsevin Reduces Intracellular Ca2+ Spark Frequency, Amplitude, and Cytosolic Ca2+ Clearance Leading to a Restriction of Individual Ca2+ Sparks
(A) Representative line scan confocal images from RyR2R4496C/WT cardiomyocytes show spontaneous Ca2+ sparks. (B) Treatment with ISO induced a higher spark frequency and amplitude and accelerated cytosolic Ca2+ removal (taudecay) leading to narrower (full width) and shorter (full duration) sparks. Administration of efsevin reduced Ca2+ spark frequency (p = 0.049, Kruskal Wallis test) and amplitude (p < 0.001, Kruskal Wallis test) and limited spatial (p < 0.001, Kruskal Wallis test) and temporal (p = 0.002, Kruskal Wallis test) expansion of Ca2+ sparks. Abbreviations as in Figure 1.