Author + information
- Received November 19, 2018
- Revision received February 15, 2019
- Accepted February 19, 2019
- Published online June 24, 2019.
- Claudio Humeres, PhD and
- Nikolaos G. Frangogiannis, MD∗ ()
- The Wilf Family Cardiovascular Research Institute, Department of Medicine (Cardiology), Albert Einstein College of Medicine, Bronx, New York
- ↵∗Address for correspondence:
Dr. Nikolaos G. Frangogiannis, The Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer G46B, Bronx, New York 10461.
• Cardiac fibroblasts become activated following injury and participate in repair and remodeling of the heart.
• The authors discuss the phenotypic alterations and role of fibroblasts in infarcted and failing hearts.
• In failing hearts, fibroblasts may deposit ECM proteins, increasing myocardial stiffness, but may also exert protective and reparative actions.
• Future studies will focus on characterization of the phenotypic heterogeneity of cardiac fibroblasts that may explain their functional diversity.
Expansion and activation of fibroblasts following cardiac injury is important for repair but may also contribute to fibrosis, remodeling, and dysfunction. The authors discuss the dynamic alterations of fibroblasts in failing and remodeling myocardium. Emerging concepts suggest that fibroblasts are not unidimensional cells that act exclusively by secreting extracellular matrix proteins, thus promoting fibrosis and diastolic dysfunction. In addition to their involvement in extracellular matrix expansion, activated fibroblasts may also exert protective actions, preserving the cardiac extracellular matrix, transducing survival signals to cardiomyocytes, and regulating inflammation and angiogenesis. The functional diversity of cardiac fibroblasts may reflect their phenotypic heterogeneity.
Dr. Frangogiannis’s laboratory is supported by National Institutes of Health grants R01 HL76246 and R01 HL85440 and by U.S. Department of Defense grants PR151134 and PR151029. Dr. Humeres is supported by American Heart Association post-doctoral award 19POST34450144. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
All authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and U.S. Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Basic to Translational Science author instructions page.
- Received November 19, 2018.
- Revision received February 15, 2019.
- Accepted February 19, 2019.
- 2019 The Authors
- Central Illustration
- Fibroblasts in Cardiac Homeostasis
- Phenotypic Changes and Role of Cardiac Fibroblasts in the Infarcted Myocardium
- The Fibroblasts in the Pressure-Overloaded Myocardium
- Fibroblasts in the Volume-Overloaded Heart
- Fibroblast Activation in the Aging and Diabetic Heart
- Conclusions and Future Directions