Semaglutide Lowered TG and Prevented WD-Induced Transcriptional Changes in Liver of LDLr−/− Mice
(A) WD-induced increases of liver triglycerides were dose-dependently reduced by semaglutide: $$p = 0.0017, **p = 0.0045, ****p <0.0001 versus vehicle WD. (B) Semaglutide partially prevented WD induced increases in collagen gene expression: Benjamini-Hochberg-corrected p values: **p < 0.01; *p < 0.05 versus vehicle, WD. (C) Graphic representation of relative gene expression changes by WD and semaglutide compared to vehicle, chow. Benjamini-Hochberg-corrected p values: ****p < 0.0001, ***p < 0.001, **p < 0.01; *p < 0.05 versus vehicle, WD. Uncorrected and Benjamini-Hochberg-corrected p values for Figures 5B and 5C can be found in Supplemental Table S4. TG = triglyceride.