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Aortic Plaque Lesion Development Is Attenuated by Semaglutide (LDLr−/− and ApoE−/− Mice), and Liraglutide (ApoE−/− Mice), Together With a Significant Reduction in Carotid Intima Thickening
(A) Liraglutide in ApoE-/- mice significantly decreased plaque lesion development: ∗p = 0.0383, ∗∗∗p = 0.0002 versus vehicle WD, and (B) carotid intima thickening: ∗p = 0.0279 vs vehicle WD. (C) Semaglutide significantly decreased WD induced plaque lesion development at all dose levels in ApoE-/- mice: ∗p = 0.0266, ∗∗p = 0.0046, ∗∗∗∗p < 0.0001 versus vehicle WD, and (D) LDLr-/- mice: ∗∗∗∗p < 0.0001 versus vehicle WD. (E) Representive en face images from aortas. Resolution: 0.0677 pixels/μm. ApoE = apolipoprotein E; LDLr = low-density lipoprotein receptor; WD = Western diet.