Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice
Martin Mackasey, Emmanuel E. Egom, Hailey J. Jansen, Rui Hua, Motahareh Moghtadaei, Yingjie Liu, Jaspreet Kaur, Megan D. McRae, Oleg Bogachev, Sara A. Rafferty, Gibanananda Ray, Adam W. Kirkby and Robert A. Rose
Effects of the NPR-C Agonist cANF on Ang II-Mediated Alterations in SAN Fibrosis
(A) SAN immunohistochemistry for HCN4 (top) and picrosirius red staining of fibrosis (bottom) for wild-type mice treated with saline, Ang II, or Ang II plus cANF (0.07 or 0.14 mg/kg/day). Bars = 50 μM. (B) Summary of the effects of cANF on Ang II-mediated fibrosis in the SAN. *p < 0.001 versus saline; #p = 0.037 versus saline; +p < 0.001 versus Ang II; ∧p = 0.004 versus Ang II plus cANF (0.07) by 1-way analysis of variance with Tukey post hoc test; n = 5 hearts for each group.