Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice
Martin Mackasey, Emmanuel E. Egom, Hailey J. Jansen, Rui Hua, Motahareh Moghtadaei, Yingjie Liu, Jaspreet Kaur, Megan D. McRae, Oleg Bogachev, Sara A. Rafferty, Gibanananda Ray, Adam W. Kirkby and Robert A. Rose
Assessment of Heart Rate and SAN Function in Wild-Type Mice Co-Treated With Ang II and the NPR-C Agonist cANF
(A) Representative ECG recordings and SNRT measurements during intracardiac programmed stimulation in wild-type mice treated with saline, Ang II. or Ang II plus cANF (0.07 or 0.14 mg/kg/day). (B) (C) Summary of heart rate (B) and cSNRT (C) in wild-type mice treated with saline, Ang II, or Ang II plus cANF (0.07 or 0.14 mg/kg/day). (B) *p < 0.001 versus saline; +p = 0.009 versus Ang II; ˆp = 0.006 versus Ang II plus cANF (0.07). (C) *p < 0.001 versus saline; +p < 0.001 versus Ang II; ∧p = 0.006 versus Ang II plus cANF (0.07). Data were analyzed by 1-way analysis of variance with Tukey post hoc test; n = 28 mice for saline, 29 mice for Ang II, 20 mice for Ang II plus cANF (0.07 mg/kg/day) and 22 mice for Ang II plus cANF (0.14 mg/kg/day). cANF = NPR-C agonist; other abbreviations as in Figure 1.