Natriuretic Peptide Receptor-C Protects Against Angiotensin II-Mediated Sinoatrial Node Disease in Mice
Martin Mackasey, Emmanuel E. Egom, Hailey J. Jansen, Rui Hua, Motahareh Moghtadaei, Yingjie Liu, Jaspreet Kaur, Megan D. McRae, Oleg Bogachev, Sara A. Rafferty, Gibanananda Ray, Adam W. Kirkby and Robert A. Rose
Effects of Ang II on Interstitial Fibrosis in the SAN of Wild-Type and NPR-C−/− Mice
(A) Sections through the SAN in wild-type and NPR-C−/− mice treated with saline or Ang II. For each treatment group, the top image illustrates the HCN4-positive zone (green) used to identify the SAN region, and the bottom image illustrates the picrosirius red staining from an adjacent section used to identify fibrosis (red). Bars = 50 μM. (B) Summary of SAN fibrosis measured in the HCN4-positive zone for wild-type and NPR-C−/− mice treated with saline or Ang II. *p < 0.001 versus saline; +p = 0.014 versus wild type by 2-way analysis of variance with Tukey post hoc test; n = 5 hearts for each group.