Author + information
- Lukas Bereuter, MSca,b,∗ (, )
- Mirco Gysin, MScb,
- Thomas Kueffer, MSca,b,
- Martin Kucera, MScc,
- Thomas Niederhauser, PhDc,
- Jürg Fuhrer, MDa,
- Paul Heinisch, MDd,
- Adrian Zurbuchen, PhDe,
- Dominik Obrist, PhDb,
- Hildegard Tanner, MDa and
- Andreas Haeberlin, MD, PhDa,b
- aDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
- bARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland
- cInstitute for Human Centered Engineering, Bern University of Applied Sciences, Biel, Switzerland
- dDepartment of Cardiovascular Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
- eElectrical Engineering and Computer Science Department, University of Michigan, Ann Arbor, Michigan
- ↵∗Address for correspondence:
Mr. Lukas Bereuter, ARTORG Center, Murtenstrasse 50, 3008 Bern, Switzerland.
• The new leadless pacemakers overcome important limitations of conventional devices but only provide single-chamber pacing capability.
• The presented concept involves 2 leadless pacemakers that communicate wirelessly with each other and thus enable synchronized leadless dual-chamber pacing.
• A novel technology is presented for pacemaker communication, using the myocardium and blood as the transmission medium. Optimal communication parameters were assessed in vivo and in vitro, and various features having an influence on signal transmission have been identified.
• A leadless dual-chamber pacemaker prototype was developed and successfully tested in vivo.
• The presented technique has shown to be a promising and energy-efficient wireless communication method for leadless dual-chamber pacemakers.
Contemporary leadless pacemakers only feature single-chamber pacing capability. This study presents a prototype of a leadless dual-chamber pacemaker. Highly energy-efficient intrabody communication was implemented for wireless pacemaker synchronization. Optimal communication parameters were obtained by in vivo and ex vivo measurements in the heart and blood. The prototype successfully performed dual-chamber pacing in vivo. The presented wireless communication method may in the future also enable leadless cardiac resynchronization therapy.
- intrabody communication
- leadless dual-chamber pacing
- leadless pacemaker
- low power
- wireless communication
This study was supported by the research funds of the Department of Cardiology, Bern University Hospital, the Swiss Heart Foundation, and the Swiss Foundation for Pacemaker and Electrophysiology. All authors have reported that they have no relationships relevant to the contents of this paper to disclose.
All authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Basic to Translational Science author instructions page.
- Received July 5, 2018.
- Accepted July 19, 2018.
- 2018 The Authors