Exercise capacity was evaluated in all study groups at 18 weeks following TAC surgery. (A) Duration (min) of the running before exhaustion. (B) Distance (m) of the running before exhaustion. (C) Shocks per minute in mice from Sham, HF + Control, HF + JK-1 3 weeks post TAC, and HF + JK-1 10 weeks post TAC groups at 18 weeks post TAC. All data were analyzed with 1-way ANOVA. Circles inside bars denote the sample size. Abbreviations as in Figure 1.