(A) Representative images (original magnification ×20) of Picrosirius red-stained cardiac tissue sections from HF + Control and HF + JK-1 (3 weeks and 10 weeks, respectively) delayed treatment. (B) Quantified cardiac fibrosis. (C) Relative fold changes in myocardial mRNA levels of a panel of fibrosis-related genes in mice from HF + Control, HF + JK-1 3 weeks post TAC, and HF + JK-1 10 weeks post TAC groups at 18 weeks post TAC. All data in Figure 3 were analyzed with 1-way ANOVA. Circles inside bars denote sample size. Abbreviations as in Figure 1.