Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms
Marcelo H. Petri, Silke Thul, Teodora Andonova, Moritz Lindquist-Liljeqvist, Hong Jin, Nikolaos-Taxiarchis Skenteris, Hildur Arnardottir, Lars Maegdefessel, Kenneth Caidahl, Mauro Perretti, Joy Roy and Magnus Bäck
Decreased Adventitial ALX/FPR2 Expression in Human AAA
(A) ALX/FPR2 expression in the media and adventitia derived from 13 control aortas from organ donors, 76 thrombus-covered AAA, and 34 nonthrombus-covered AAA segments. (B) Correlations between the neutrophil markers CD66b and CD66d in AAA samples (n = 76). (C) Immunohistochemical analysis of ALX/FPR2 revealed predominant adventitial expression in AAA samples, and at higher magnification, polymorphonuclear cells positive for ALX/FPR2 were identified. AAA = abdominal aortic aneurysms.