|1.||The genetic variants inherited from each parent are randomly assigned at conception.|
|2.||The association between the genetic variant and the disease remains unchanged because germline DNA does not change during one’s lifetime.|
|3.||The genetic variant, transmitted by the parents as a DNA sequence, is not confounded by environmental factors such as dietary, lifestyle, environmental, or socioeconomic factors.|
|4.||The disease process does not alter the germline genotype, therefore the association between genetic variant and disease is not influenced by reversed causality.|
|5.||The genetic variant remains fixed throughout life, providing for the assessment of a lifetime exposure.|
|6.||There is no problem with compliance because the genetic variant is fixed for life.|
|7.||Because germline DNA remains unchanged throughout life, there is no regression dilution effect.|
MR = Mendelian randomization.