Ticagrelor Reduces Inflammation, Increases Lung Function, and Protects Against Mortality in a Murine Sepsis Model
The concentrations of TNF-α (A) and IL-10 (B) at 0 h up to 8 h post-LPS injection are graphed for control mice and mice treated with ticagrelor or clopidogrel (A and B, reported as mean with bar indicating SE). Significant difference over the time course compared with the control is indicated by an asterisk in A and B. Survival curves of wild-type (WT) mice and P2y12−/− mice injected with LPS are plotted in C, whereas D shows survival curves of WT and P2y12−/− mice treated with clopidogrel or ticagrelor (T10) before LPS injection. Significance between mutant and WT (A) and P2Y12 antagonist treated and untreated (D) is indicated by an asterisk. Capillary filtration coefficients (KFC) are graphed for control mice and mice treated with ticagrelor or clopidogrel (E, reported as mean with bar indicating SE). Significant differences between treatment group and control are indicated by an asterisk. IL = interleukin; LPS = lipopolysaccharide; TNF = tumor necrosis factor.