In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents
Nabil E. Boutagy, Jing Wu, Zhengxi Cai, Wenjie Zhang, Carmen J. Booth, Tassos C. Kyriakides, Daniel Pfau, Tim Mulnix, Zhao Liu, Edward J. Miller, Lawrence H. Young, Richard E. Carson, Yiyun Huang, Chi Liu and Albert J. Sinusas
Transthoracic Echocardiography–Derived Systolic Function and Ventricular Dimensions
(A) Ejection fraction, (B) global longitudinal strain, (C) global radial strain, (D) left ventricular (LV) end-diastolic volume, (E) end-systolic volume, and (F) relative wall thickness at baseline (CTL, n = 10; DOX, n = 10), and 4 weeks (CTL, n = 10; DOX, n = 10), 6 weeks (CTL, n = 5; DOX, n = 5), and 8 weeks (CTL, n = 5; DOX, n = 4) following the initiation of chemotherapy in DOX-treated rats and time-matched controls. *p < 0.01 between-group difference. Box plots display the median (horizontal bar), first quartile, third quartile, and minimum and maximum values (whiskers). LVPwd = left ventricular posterior wall thickness at end-diastole; LVID = left ventricular internal diameter; other abbreviations as in Figure 1.