Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction
Thomas E. Sharp III, Hajime Kubo, Remus M. Berretta, Timothy Starosta, Markus Wallner, Giana J. Schena, Alexander R. Hobby, Daohai Yu, Danielle M. Trappanese, Jon C. George, Jeffery D. Molkentin and Steven R. Houser
Echocardiography was performed before, 1 month (Mo), 2Mo, and 3Mo post-myocardial infarction (PMI). (A) Left ventricular (LV) end-diastolic volume (LVEDV), (B) end-systolic volume (LVESV), and (C) ejection fraction (LVEF) images were acquired using the 2-dimensional parasternal long-axis view. Calculation was performed using the Simpson method. Open bars represent before MI, red bars represent PMI. *p ≤ 0.05; **p ≤ 0.005; ***p ≤ 0.005; ****p ≤ 0.005 versus baseline.