Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction
Thomas E. Sharp III, Hajime Kubo, Remus M. Berretta, Timothy Starosta, Markus Wallner, Giana J. Schena, Alexander R. Hobby, Daohai Yu, Danielle M. Trappanese, Jon C. George, Jeffery D. Molkentin and Steven R. Houser
Protocol used to induce acute myocardial infarction (MI) and functionally assess the progression of pathological remodeling. Timeline for delivery of dobutamine (DOB) and ruboxistaurin (RBX) at 3 months’ post-MI. LAD = left anterior descending coronary artery.